| Accession |
PMDE10 |
| Name |
CRL4(CRBN) ubiquitin ligase profiling |
| Description |
In the 1950s the drug thalidomide administered as a sedative to pregnant women led ot the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and ist IMiD derivatives recently emerged as effective treatments for multiple myeloma and 5q-dysplasia. IMiDs target the CUL4-RBX1-DDB1-CRBN (CRL4(CRBN)) ubiquitin ligase.
Through an unbiased screen we identify the homeobox trranscription factor MEIS2 as an endogenous substrate of CRL4(CRBN). |
| Publication |
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
(Go to PubMed)
|
| Provider |
Eric S Fischer |
| Species |
Homo sapiens |
| Subspecies |
Empty
|
| Array type |
Multi-array |
| Sample |
Serum |
| Number of array |
16 |
| Array(1) |
Invitrogen ProtoArray v5.0 (full array layout)
|
| Raw data |
download
|
| Experiment details |
download
|
| Analysis report |
No relevant analysis report. If you want to analyse this data, please contact us. |
| Link to GEO |
GSE57554
|
