Accession PMDE142
Name Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
Description Opossums carry a rare KYNU H4 domain that abolishes 2F5 binding, but retain all SF3B3 4E10 epitopes. Immunization of opossums with HIV-1 gp140 induced extraordinary titers of serum antibody to the 2F5 ELDKWA epitope but little or nothing to the 4E10 determinant. Identification of structural motif shared by vertebrates and HIV-1 provides direct evidence that immunological tolerance can impair humoral responses to HIV-1.
Publication Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies (Go to PubMed)
Provider Guang Yang
Species Homo sapiens
Subspecies Empty
Array type Proteome array
Sample Cell lysate
Number of array 4
Array(2) Invitrogen ProtoArray v5.0 Antigen Discovery Vaccinia virus (strain WR) proteome microarray
Raw data download
Experiment details download
Analysis report No relevant analysis report. If you want to analyse this data, please contact us.
Link to GEO

GSE42673