| Accession |
266 |
| Title |
Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array |
| Summary |
In this study we used an EGFR-phosphorylatable peptide, AEEEEYFELVAKKK, immobilized within a polyacrylamide hydrogel as a substrate for profiling the activation status of EGFR in the cellular extracts of erlotinib-resistant cancer cells. The hydrogel array was able to detect therapeutic resistance as well as identify inhibitors capable of combating therapeutic resistance. |
| Journal |
Biosens Bioelectron |
| Publish date |
August, 2010 |
| Corresponding Author |
Sean P. Palecek |
| E-mail |
palecek@engr.wisc.edu |
| Array Type |
Technological development of protein array |
| Species |
|
| Raw data link |
No relevant experiment link!
|
| Link to PubMed |
PubMed ID:20729058
|
