| Accession |
278 |
| Title |
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells |
| Summary |
Quantitative assessment of phospho-protein levels in the Braf-mutant cell lines by reverse phase protein array (RPPA) analysis showed no significant association between P-MEK or P-MAPK levels and AZD6244 sensitivity, but activation-specific markers in the phosphoinositide 3-kinase (PI3K)-AKT pathway correlated with resistance. |
| Journal |
Cancer Res. |
| Publish date |
October, 2010 |
| Corresponding Author |
Michael A. Davies |
| E-mail |
mdavies@mdanderson.org |
| Array Type |
Reverse phase protein array |
| Species |
Homo sapiens |
| Raw data link |
No relevant experiment link!
|
| Link to PubMed |
PubMed ID:20959481
|
