| Accession | 290 |
| Title | β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation |
| Summary | Using information gleaned from a peptide array, we developed a cell-permeant peptide that serves to inhibit the interaction of these proteins. Using this peptide, we demonstrate that disruption of the β-arrestin 1/ARHGAP21 complex results in a more active ARHGAP21, leading to less-efficient signaling via the angiotensin II type 1A receptor and, thereby, attenuation of stimulated stress fiber formation. |
| Journal | Mol Cell Biol. |
| Publish date | December, 2010 |
| Corresponding Author | G. S. Baillie |
| G.Baillie@bio.gla.ac.uk | |
| Array Type | Peptide array |
| Species | Homo sapiens |
| Raw data link | No relevant experiment link! |
| Link to PubMed |