Accession 333
Title Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Summary We show here that primary human omental adipocytes promote homing, migration and invasion of ovarian cancer cells, and that adipokines including interleukin-8 (IL-8) mediate these activities. A protein array identified upregulation of fatty acid-binding protein 4 (FABP4, also known as aP2) in omental metastases as compared to primary ovarian tumors, and FABP4 expression was detected in ovarian cancer cells at the adipocyte-tumor cell interface.
Journal Nat Med.
Publish date October, 2011
Corresponding Author Ernst Lengyel
Array Type Reverse phase protein array
Species Homo sapiens
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:22037646