Accession 451
Title SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
Summary We used protein array technology to identify the MAP3K2 kinase as a target of SMYD3. In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.
Journal Nature
Publish date May, 2014
Corresponding Author Julien Sage; Or Gozani
Array Type Proteome array
Species Homo sapiens
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:24847881