| Accession |
451 |
| Title |
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer |
| Summary |
We used protein array technology to identify the MAP3K2 kinase as a target of SMYD3. In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis. |
| Journal |
Nature |
| Publish date |
May, 2014 |
| Corresponding Author |
Julien Sage; Or Gozani |
| E-mail |
julsage@stanford.edu; ogozani@stanford.edu |
| Array Type |
Proteome array |
| Species |
Homo sapiens |
| Raw data link |
No relevant experiment link!
|
| Link to PubMed |
PubMed ID:24847881
|
