| Accession |
504 |
| Title |
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis |
| Summary |
We evaluated whether N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a recently described pan-PAD inhibitor, could affect the development of arthritis and autoimmunity by treating mice in the CIA model with Cl-amidine on days 0-35. Synovial microarray analyses demonstrated decreased IgG reactivity to several native and citrullinated epitopes compared with vehicle controls. |
| Journal |
J Immunol |
| Publish date |
February, 2011 |
| Corresponding Author |
V. Michael Holers; Paul R. Thompson |
| E-mail |
michael.holers@ucdenver.edu; pthompso@scripps.edu |
| Array Type |
Proteome array |
| Species |
Mus musculus |
| Raw data link |
PMDE47
|
| Link to PubMed |
PubMed ID:21346230
|
