Accession 505
Title Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis
Summary By performing kinase assays with site-specifically phospho- and glyco-modified CK2α in combination with CK2β and Pin1 binding partners on human protein microarrays, we show that the kinase substrate selectivity of CK2 is modulated by these specific post-translational modifications. This study suggests how a promiscuous protein kinase can be regulated at multiple levels to achieve particular biological outputs.
Journal Nat Chem Biol.
Publish date January, 2012
Corresponding Author Philip A Cole
Array Type Proteome array
Species Homo sapiens
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Link to PubMed

PubMed ID:22267120