| Accession |
PMDE108 |
| Name |
Profiling proteome-scale antibody responses to M. tuberculosis proteins in sera of macaques infected with M. tuberculosis |
| Description |
Human infection with Mycobacterium tuberculosis results in a continuum of ill-defined, clinical manifestations with stable latent M. tuberculosis infection (LTBI) and severe active disease at the ends. Identifying different states of infection is of importance to tuberculosis (TB) control since risk of developing active disease varies among different asymptomatic states while infectiousness varies among patients with different bacterial burden. We investigated changes in proteome-scale antibody responses during disease progression in a non-human primate model of tuberculosis. We probed M. tuberculosis proteome microarrays with serial sera collected from three infection-outcome groups (active, reactivation, and latent). We found that each infection outcome is associated with characteristic changes in the antibody levels and number of antigenic targets, which suggested an association between antibody responses and bacillary burden. Additional proteome-scale serological profiling of > 400 human TB suspects established that antibody responses are positively associated with bacterial load. Thus tuberculosis-specific antibody levels and number of antigenic targets increases with disease progression. |
| Publication |
Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients.
(Go to PubMed)
|
| Provider |
Shajo Kunnath-Velayudhan |
| Species |
Mycobacterium tuberculosis |
| Subspecies |
Empty
|
| Array type |
Proteome array |
| Sample |
Antibody |
| Number of array |
127 |
| Array(1) |
Mycobacterium tuberculosis H37Rv proteome microarray
|
| Raw data |
download
|
| Experiment details |
download
|
| Analysis report |
No relevant analysis report. If you want to analyse this data, please contact us. |
| Link to GEO |
No relevant GEO link!
|
