| Accession |
PMDE142 |
| Name |
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies |
| Description |
Opossums carry a rare KYNU H4 domain that abolishes 2F5 binding, but retain all SF3B3 4E10 epitopes. Immunization of opossums with HIV-1 gp140 induced extraordinary titers of serum antibody to the 2F5 ELDKWA epitope but little or nothing to the 4E10 determinant. Identification of structural motif shared by vertebrates and HIV-1 provides direct evidence that immunological tolerance can impair humoral responses to HIV-1. |
| Publication |
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
(Go to PubMed)
|
| Provider |
Guang Yang |
| Species |
Homo sapiens |
| Subspecies |
Empty
|
| Array type |
Proteome array |
| Sample |
Cell lysate |
| Number of array |
4 |
| Array(2) |
Invitrogen ProtoArray v5.0
Antigen Discovery Vaccinia virus (strain WR) proteome microarray
|
| Raw data |
download
|
| Experiment details |
download
|
| Analysis report |
No relevant analysis report. If you want to analyse this data, please contact us. |
| Link to GEO |
GSE42673
|
