Accession PMDE18
Name Diversity of antibody responses to Borrelia burgdorferi in experimentally-infected beagle dogs
Description Lyme borreliosis (LB) is a common infection of domestic dogs in areas where there is enzootic transmission of the agent Borrelia burgdorferi. Immunodiagnostic assays for canine antibodies to B. burgdorferi are usually based on whole-cell preparations as substrate and, consequently, interpretation of results is confounded by antibody cross-reactivity between borrelial antigens and those of other bacterial species. To more broadly characterize the antibody responses to B. burgdorferi infection and to assess the diversity in those responses between individual dogs, we examined sera from 32 adult, colony-bred beagle dogs that were experimentally infected with B. burgdorferi through tick bites and compared those on a protein microarray with sera from uninfected dogs in their antibody reactivities to various recombinant chromosome- and plasmid-encoded B. burgdorferi proteins, including 24 of the serotype-defining OspC proteins of North America. The profiles of immunogenic proteins for the dogs were largely similar to those for humans and natural reservoir rodents.
Publication Diversity of antibody responses to Borrelia burgdorferi in experimentally-infected beagle dogs (Go to PubMed)
Provider Elisabeth Baum
Species Canis lupus familiaris
Subspecies Empty
Array type Proteome array
Sample Cell lysate
Number of array 36
Array(1) Borrelia burgdorferi Partial Genome Array
Raw data download
Experiment details download
Analysis report No relevant analysis report. If you want to analyse this data, please contact us.
Link to GEO

GSE50075

GSE50074