| Accession |
PMDE18 |
| Name |
Diversity of antibody responses to Borrelia burgdorferi in experimentally-infected beagle dogs |
| Description |
Lyme borreliosis (LB) is a common infection of domestic dogs in areas where there is enzootic transmission of the agent Borrelia burgdorferi. Immunodiagnostic assays for canine antibodies to B. burgdorferi are usually based on whole-cell preparations as substrate and, consequently, interpretation of results is confounded by antibody cross-reactivity between borrelial antigens and those of other bacterial species. To more broadly characterize the antibody responses to B. burgdorferi infection and to assess the diversity in those responses between individual dogs, we examined sera from 32 adult, colony-bred beagle dogs that were experimentally infected with B. burgdorferi through tick bites and compared those on a protein microarray with sera from uninfected dogs in their antibody reactivities to various recombinant chromosome- and plasmid-encoded B. burgdorferi proteins, including 24 of the serotype-defining OspC proteins of North America. The profiles of immunogenic proteins for the dogs were largely similar to those for humans and natural reservoir rodents. |
| Publication |
Diversity of antibody responses to Borrelia burgdorferi in experimentally-infected beagle dogs
(Go to PubMed)
|
| Provider |
Elisabeth Baum |
| Species |
Canis lupus familiaris |
| Subspecies |
Empty
|
| Array type |
Proteome array |
| Sample |
Cell lysate |
| Number of array |
36 |
| Array(1) |
Borrelia burgdorferi Partial Genome Array
|
| Raw data |
download
|
| Experiment details |
download
|
| Analysis report |
No relevant analysis report. If you want to analyse this data, please contact us. |
| Link to GEO |
GSE50075
GSE50074
|
