| Accession |
PMDE19 |
| Name |
Molecular basis of 9G4 B cell autoreactivity in human SLE |
| Description |
9G4+ IgG antibodies expand in SLE in a disease specific fashion and react with different lupus antigens including B cell antigens and apoptotic cells. Their shared use of VH4-34 represents a unique system to understand the molecular basis of lupus autoreactivity. Understanding the participation of apoptotic cells, a rich source of self-antigens including chromatin, in the diversification and selection of autoreactive memory B cells is particularly important in SLE where these cells accumulate in the germinal centers and may activate pathogenic autoreactive B cells. Our findings indicate that the three mabs with strong apoptotic binding recognized chromatin and individual histones as documented by glomerular proteome microarrays. While the actual antigens mediating APCB remain to be formally elucidating, our initial studies indicate that binding to histone/chromatin may mediate such autoreactivity in at least a fraction of these antibodies |
| Publication |
Molecular basis of 9G4 B cell autoreactivity in human SLE
(Go to PubMed)
|
| Provider |
yun lian |
| Species |
Homo sapiens |
| Subspecies |
Empty
|
| Array type |
Reverse phase protein array |
| Sample |
Cell lysate |
| Number of array |
3 |
| Array(1) |
Multi-species Autoantigen Microarray
|
| Raw data |
download
|
| Experiment details |
download
|
| Analysis report |
No relevant analysis report. If you want to analyse this data, please contact us. |
| Link to GEO |
GSE50609
|
