Accession PMDE19
Name Molecular basis of 9G4 B cell autoreactivity in human SLE
Description 9G4+ IgG antibodies expand in SLE in a disease specific fashion and react with different lupus antigens including B cell antigens and apoptotic cells. Their shared use of VH4-34 represents a unique system to understand the molecular basis of lupus autoreactivity. Understanding the participation of apoptotic cells, a rich source of self-antigens including chromatin, in the diversification and selection of autoreactive memory B cells is particularly important in SLE where these cells accumulate in the germinal centers and may activate pathogenic autoreactive B cells. Our findings indicate that the three mabs with strong apoptotic binding recognized chromatin and individual histones as documented by glomerular proteome microarrays. While the actual antigens mediating APCB remain to be formally elucidating, our initial studies indicate that binding to histone/chromatin may mediate such autoreactivity in at least a fraction of these antibodies
Publication Molecular basis of 9G4 B cell autoreactivity in human SLE (Go to PubMed)
Provider yun lian
Species Homo sapiens
Subspecies Empty
Array type Reverse phase protein array
Sample Cell lysate
Number of array 3
Array(1) Multi-species Autoantigen Microarray
Raw data download
Experiment details download
Analysis report No relevant analysis report. If you want to analyse this data, please contact us.
Link to GEO