| Accession |
PMDE31 |
| Name |
Inferring Epitopes of a Polymorphic Antigen Amidst Broadly Cross-Reactive Antibodies Using Protein Microarrays: a Study of OspC Proteins of Borrelia burgdorferi |
| Description |
Epitope mapping studies aim to identify the binding sites of antibody-antigen interactions to enhance the development of vaccines, diagnostics and immunotherapeutic compounds. However, mapping is a laborious process employing time- and resource-consuming ‘wet bench’ techniques or epitope prediction software that are still in their infancy. For polymorphic antigens, another challenge is characterizing cross-reactivity between epitopes, teasing out distinctions between broadly cross-reactive responses, limited cross-reactions among variants and the truly type-specific responses. A refined understanding of cross-reactive antibody binding could guide the selection of the most informative subsets of variants for diagnostics and multivalent subunit vaccines. |
| Publication |
Inferring Epitopes of a Polymorphic Antigen Amidst Broadly Cross-Reactive Antibodies Using Protein Microarrays: a Study of OspC Proteins of Borrelia burgdorferi
(Go to PubMed)
|
| Provider |
Elisabeth Baum |
| Species |
Homo sapiens |
| Subspecies |
Empty
|
| Array type |
Peptide array |
| Sample |
Cell lysate |
| Number of array |
110 |
| Array(1) |
OspC Protein Microarray
|
| Raw data |
download
|
| Experiment details |
download
|
| Analysis report |
No relevant analysis report. If you want to analyse this data, please contact us. |
| Link to GEO |
No relevant GEO link!
|
