Accession PMDE40
Name Substrate phosphorylation of protein microarray by leucine-rich repeat kinase 2
Description Numerous leucine-rich repeat kinase 2 mutations identified throughout the protein are associated with Parkinson disease, however the activating G2019S kinase domain mutation is currently regarded as the most common cause of familial and sporadic forms of this disorder. Despite studies demonstrating the prominent role that its kinase activity plays in the pathobiology of leucine-rich repeat kinase 2, few substrates have been identified and only a subset of these have been linked to disease. Therefore, we utilized protein microarrays to screen over 9,000 human proteins in an unbiased radiometric assay for potential targets of the kinase.
Publication Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells (Go to PubMed)
Provider Jason Covy
Species Homo sapiens
Subspecies Empty
Array type Proteome array
Sample Enriched peptide
Number of array 1
Array(1) Invitrogen ProtoArray v5.0
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Analysis report No relevant analysis report. If you want to analyse this data, please contact us.
Link to GEO