Accession PMDE58
Name Fibrinogen-reactive T cells transfer disease to naive mice
Description Splenocytes harvested from mice with FIA were cultured in vitro and stimulated with 0.01 mg/ml fibrinogen for 3 days. Enriched T cells were transferred into 6-week-old na?ve SJL mice, which developed visible signs of arthritis within 2 weeks. Synovial array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B cell responses against peptides representing native fibrinogen, and further spreading of the responses to target collagen type V, cartilage gp39, and citrullinated vimentin.
Publication Autoimmunity against fibrinogen mediates inflammatory arthritis in mice (Go to PubMed)
Provider William Robinson
Species Mus musculus
Subspecies Empty
Array type Proteome array
Sample Cell lysate
Number of array 9
Array(1) Synovial protein array 0.5K v2.0
Raw data download
Experiment details download
Analysis report analysis report download
Link to GEO