Accession 625
Title Broad Spectrum Antibodies to Self-Antigens and Cytokines in RAG Deficiency
Summary By using multiple methods (microarray, ELISA and multiplex bead technology), we have consistently identified a distinctive signature of anti-cytokine antibodies in patients with RAG-dependent immunodeficiencies, especially in those with CID-G/AI and a history of severe viral infections. These autoantibodies were not detected in a large panel of patients with other forms of primary immunodeficiency, and may therefore represent a novel biomarker panel of this condition.
Journal J. Clinical Investigation
Publish date In press, 2015
Corresponding Author Christopher H. Contag
Array Type Proteome array
Species Homo sapiens
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